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ISSN Online: 2377-424X

ISBN Print: 978-1-56700-474-8

ISBN Online: 978-1-56700-473-1

International Heat Transfer Conference 16
August, 10-15, 2018, Beijing, China

THERMAL CHARACTERISTICS MEASUREMENT OF FIBRIN REACTION AND CLOT FORMATION IN VENOUS THROMBUS USING MICROCHANNEL FLOW

Get access (open in a dialog) DOI: 10.1615/IHTC16.bma.022842
pages 541-550

摘要

Temperature effects on the coagulation time and reaction rate coefficient of fibrin based thrombus formation were measured in this study. Coagulation time, which is the time required for the thrombus and fibrin clot to form, were evaluated using microchannel flow, micro glass capillary flow, and cuvette measurements. Fluorescence labeling technique based visualization of platelets, plasma and fibrin performed in the microchannel measurement showed that the fibrin fibers growing from the activated platelets play a major role in the initial stage of thrombus formation for low shear rate flow conditions of vein. Thermal characteristics of the fibrin generation reaction, therefore, becomes one of the key factors for thrombus formation rate in blood flow in this case. Temperature affected the fibrin formation characteristics and the coagulation time showed the minimum value at temperature of 32-42°C in the cases of with and without flows. A first order reaction model was applied to curve fitting with the time distribution of fibrin concentration obtained by the cuvette measurements to derive the reaction rate of the fibrin generation. Reaction coefficient increased as the temperature increased in the range of 24°C-37°C showing that the decrease of the coagulation time of the fibrin clot in this temperature range was attributed to faster fibrin generation reaction.