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International Heat Transfer Conference 16

ISSN: 2377-424X (online)
ISSN: 2377-4371 (flashdrive)

EFFECT ON AUTOREGULATION OF THE ATERTIAL BLOOD FLOW DURING HYPERTHERMIA

Yabo Wang
Tianjin University of Commerce, Key Laboratory of Refrigeration Technology of Tianjin, Tianjin 300134, China

Kai Zhu
Tianjin University of Commerce, Key Laboratory of Refrigeration Technology of Tianjin, Tianjin 300134, China

Jinshan Wang
Tianjin Key Laboratory of Refrigeration Technology, Tianjin University of Commerce, Tianjin, China

Yanqi Xie
Tianjin Key Laboratory of Refrigeration Technology, Tianjin University of Commerce, Tianjin, China

DOI: 10.1615/IHTC16.bma.024161
pages 591-598


KEY WORDS: Hyperthermia, Autoregulation, Blood flow, Blood vessel

Abstract

The wall of arteries and arterioles contain smooth muscles which can contract or relax in the response to various factors such as high temperature, thereby regulating the vessel lumen and flow-rate. The purpose of our study is to formulate and investigate a novel mathematical model for describing the local autoregulation of the blood flow with account for the viscoelastic behavior of the arterial wall under hyperthermia. The variation regulation of blood flow rate with temperature was obtained by experiment. The temperature controlling system is designed and dynamic blood flow is measured. The Laser Doppler was used to monitor the blood flow rate during heating process. When heating is loaded on the mouse skin, the blood flow increased sharply at the beginning and then fell to a constant value. The variation of the blood flow rate made the shear stress between the blood flow and the inner arterial surface increase, which leads to the relaxation of the smooth muscle layer in the arterial wall resulting in an increase in the artery radius and a decrease in the shear stress.

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