This paper details the heat and mass transfer at the ignition patterns of single (methane) and double (methane-isopropanol) granulated hydrates in a heated air. The experiments were performed in a laboratory-scale combustion chamber in the form of an oblong reactor with free-falling powder granules. The air in the combustion chamber was heated by the walls with ceramic plate heaters. The variation ranges of the input parameters were chosen to match the capacities of modern energy generation systems (air temperature: 873−1273 K, granule flight time in a chamber: 0.1−0.2 s, granule velocity: 3−10 m/s, granule size: 0.5−4.5 mm, and fuel consumption: 10−25 kg/h). We established the ignition delay times of hydrate granules, combustion regimes, and sizes of the flame zone behind moving granules. We also analyzed the joint influence of hydrate granules on their ignition behavior. A model was developed to estimate the threshold boundary conditions of granule flow ignition in different-sized chambers, with variable hydrate component composition granule size. Hydrate dissociation rates were determined in different sections of the laboratory-scale combustion chamber. Thermal conditions were predicted in which gas hydrates consistently ignite in combustion chambers with minimum cooling of the chamber walls and minimum unburnt fuel.