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International Heat Transfer Conference 16

ISSN: 2377-424X (online)
ISSN: 2377-4371 (flashdrive)

THE EFFECT OF THE CLUSTER’S SIZE ON HYPERTHERMIA HEATING FERROFLUIDS OF SUPERPARAMAGNETIC NANOPARTICLES CLUSTERS

Rong Fu
Research Centre for Fluids and Thermal Engineering, University of Nottingham Ningbo China, Ningbo, 315100, China; Fluids & Thermal Engineering Research Group, Faculty of Engineering, University of Nottingham, Nottingham, NG7 2RD, UK

Yuying Yan
Research Centre for Fluids and Thermal Engineering, University of Nottingham Ningbo China, Ningbo, 315100, China; Fluids & Thermal Engineering Research Group, Faculty of Engineering, University of Nottingham, Nottingham, NG7 2RD, UK

Clive Roberts
School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK

Z.Y. Lu
Fluids & Thermal Engineering Research Group, Faculty of Engineering, University of Nottingham, Nottingham, NG7 2RD, UK

Y.Y. Chen
2Fluids & Thermal Engineering Research Group, Faculty of Engineering, University of Nottingham, Nottingham, NG7 2RD, UK

DOI: 10.1615/IHTC16.bma.021923
pages 505-512


KEY WORDS: Bio and medical applications, Thermal management, superparamagnetic nanoparticles, size effect, hyperthermia heating, cancer therapy

Abstract

Magnetic nanofluid (MNF) is one special kind of nanofluid which possesses both magnetic and fluidic properties. Nowadays, investigations of MNF-based hyperthermia heating are emerging as a new frontier in studies of cancer therapy. This work aims to investigate the influence of cluster's size on hyperthermia heating the MNF of colloidal clusters of densely-packed Fe3O4 nanoparticles at low field intensity. Emulsion droplet solvent evaporation method was used to assembly oleic acid modified Fe3O4 particles into compact clusters stabilized by surfactant in water. Both experimental and simulation works were conducted to study the dependence of the heating efficiency on the cluster's size. In comparison with isolated particles, a more efficient heating could be expected only when the clusters' sizes are small enough that the clusters' shape anisotropy was enhanced. The shape anisotropy is reduced as increasing the clusters' sizes, since the clusters become more and more like spheres. Consequently, the inter-particle dipole interactions change to impair the heating efficiency. When the clusters are totally isotropic in shape, the heating efficiency keeps lower than that of isolated particles despite the cluster's size, although the efficiency can rebound by somewhat at a particular size.

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