This study investigates the novel design of an air handling system for Sub Saharan using controlled latent load. Insulating a building in hot and humid climate reduces the sensible cooling load of a building but does not necessarily decrease the latent cooling load. Without humidity control, increased indoor humidity will occur, resulting in a lower comfort feeling. The energy demanding humidity control using a reheat coil can be replaced by the Drysus air-conditioning system, a novel designed air handling system, to control the absolute humidity of the ventilation supply air in the building. The Drysus consists of a plate heat exchanger, a cooling coil section and a damper section. The damper section controls the airflow ratio of cooled air being recycled to the return side of the plate heat exchanger resulting in a ventilation supply air with fixed absolute humidity and temperature. The recycled air precools the fresh air supply and fulfills the task of reheater of the dehumidified air. Extra controls on the water flow of the cooling coil and leaving water temperature of the chiller result in an extra energy saving. The Drysus can be used as stand-alone air handling unit and replaces the ventilation unit with sorption wheel in the reference building. When used in combination with individual fan coil units per room, with only sensible cooling, the system becomes an energy efficient cooling system for hotel and multi-dwelling application. The analysis and simulation was performed using the Transys code. For the Drysus system applied in the reference building, for sub-Saharan countries located in Kisangani, Port Harcourt, Tamatave and Tabou, the results show an increase in energy savings and better thermal comfort compared to the dehumidification systems with reheat coil. Also, compared to the cooling system with fan coils without humidity control combined with balanced ventilation with sorption wheel, and a set temperature of 22.5°C, the Drysus system with set temperature of 26.5°C, results in 16 to 35% energy savings for the simulated cases.