In order to solve the problem of efficient thermal evacuation of local high heat flux, an oscillating heat pipe(OHP) with topology-optimized structure applicable to the local heating conditions of two heat sources is proposed in this paper. Two heat sources are arranged in the evaporation section of the OHP, the channel area is modeled as a region with high thermal conductivity, and the topology optimization method is used to determine the channel layout of the OHP. The OHP with conventional structure and the optimized OHP were fabricated by metal 3D printing technology. The experiments were conducted with R152a as the working fluid at different filling ratio and inclination angles. The results show that the OHP with topology-optimized structure has lower starting power and better evaporation section homogeneity compared with the conventional OHP. At the same time, the optimized OHP has a higher heat transfer limit power, a significantly lower thermal resistance of about 36.5%, and a significantly enhanced heat transfer performance.