In recent years, refrigerant blends have been proposed as alternatives because they can moderate well between the benefit of GWP reduction and favorable thermo-physical properties. Additionally, works has been underway to apply more nouveau heat exchanger design into HVAC systems, and multiport mini tube has emerged as prime candidate thanks to their compactness and high heat transfer rate. In this work, the heat transfer coefficient and pressure drop of different alternative refrigerants inside a multiport mini-channel tube was experimentally investigated. The testing mass flux range is from 100 to 500 kg/m²s, heat flux from 3 to 12 kW/m², covering the entire two phase quality range. The effect of mass flux, heat flux and vapor quality on the heat transfer coefficient as well as pressure drop is analyzed and discussed. Finally, heat transfer coefficient and pressure drop is compared against different past correlation, and new correlation proposed in order to achieve the higher predictive accuracy.