The results of experimental studies of the characteristics of droplet and particle collisions of the most widely used components of promising slurry fuels: biomass, coal, cake, water, used engine oil are presented. The modes of collision of drops and particles, as well as the characteristics of secondary fragments obtained by the decay of parent drops, are established. Maps of interaction modes of droplets and particles are constructed with variation of Weber numbers in the range from 3 to 55. The conditions for agglomeration of droplets and particles for the preparation of slurry droplets, as well as their intensive secondary grinding in order to intensify ignition and subsequent combustion, are established. According to the results of a comparative analysis, it was determined that when a water drop collides with a particle of peanut husk, a greater number of secondary fragments are formed relative to particles of pine, cedar, coal and cake due to differences in their wettability and surface characteristics. It has been established that the particle shape has a dominant effect on fragmentation. Substantiated is the significant influence of the wetness of the surface of the solid component of slurry fuel on the regimes and consequences of collision with liquid drops. Recommendations are formulated on the application of research results for the development of technologies for the secondary grinding of fuel droplets and the generation of multicomponent droplets of slurry fuels directly in combustion chambers at the intersection of liquid spray jets and solid crushed substances.