Boiling is an efficient mode for heat dissipation implemented in microelectronic devices. However, there are operating temperature limits (below 85 °C) in those microelectronic components, which means that suitable coolants and heat transfer enhanced technology are crucial for further application. The hydrofluoroether fluid, HFE-7100, possesses superior environmental properties and a low boiling point (T_sat = 59.8 °C at 1 atm) which can satisfy the requirement for engineered surfaces. However, the hysteresis phenomenon occurred before triggering nucleate boiling due to the high wettability of the HFE-7100. In this study, boiling experiments were developed to examine the surface temperature for the onset of the nucleate boiling (ONB) with a porous ceramic plate attached to the indium tin oxide (ITO) heater by using HFE-7100 liquid at saturated conditions. The temperature distribution of the boiling surface was confirmed by the infrared (IR) camera. Based on the results of the experiment, the surface superheat at the ΔT_ONB was reduced by 14 K at most on the porous plate compared with the plain surface (ΔT_ONB = 39.0 K). However, the ΔT_ONB was observed to be sensitive to the liquid immersion time on the porous plate, it showed a deteriorating trend, the ΔT_ONB was almost the same as the plain surface after immersing the porous plate into HFE-7100 for 96 hours. Therefore, a heated fine wire with a continuous small input power was used to re-activate nucleate cavities, which result in maintaining the ΔT_ONB at a desirable degree (ΔT_ONB = 7.4~7.5 K) after immersion.