The direct CO₂/CH₄ exchange in the water cages of natural gas hydrate reservoirs, is probably one of the most promising solutions to get a carbon neutral and alternative energy source, enough abundant to cover the transition towards a scenario exclusively dominated be renewable energy sources. Among the several strategies thought in the last decades, depressurization and thermal stimulation seem to be the most attractive in terms of energy produced/energy spent ratio. Both of them are based on changing the local thermodynamic conditions and move the system within a region of instability for methane and, at the same time, of stability for carbon dioxide hydrates. With depressurization, the local pressure is lowered, while temperature is kept constant. Conversely, in case of thermal stimulation, the local temperature is increased, while pressure remains unvaried. However, the depressurization method was found to have higher efficiency than the other. This higher efficiency, together with the easier application, made it commonly preferred, especially in field applications. In this article, such difference was experimentally validated and showed on a confined environment and the results obtained can be extended to natural reservoirs. To do this, the replacement process was carried out with both the techniques and the results were then compared among each other.