DNA amplification-based detection methodologies are of greater usefulness owing to their high efficacy. Polymerase Chain Reaction or PCR has been the conventional DNA amplification methodology that is followed worldwide. However, PCR technology requires a proper Lab-based environment, heavy machinery, and a greater amount of time for executing the detection process. One of the other major bottlenecks in the PCR technology is the usage of a thermal cycler since PCR utilizes three different temperature cycles (Denaturation − 92°C-95°C, Annealing − 54°C-56°C and Elongation − 72°C-73°C). In most cases, almost 35-40 thermal cycles have been found to be necessary for generating a significant number of DNA strands for effective detection and analysis. Achieving such fluctuating temperature cycles in POC settings is extremely challenging and energy-consuming since both the heaters and coolers must be used efficiently without which mechanical stresses will be induced resulting in device damage. Loop-Mediated Isothermal Amplification reaction better known as LAMP utilizes the strand displacement mechanism for DNA amplification and the major advantage of LAMP is the usage of an isothermal environment for DNA amplification. Hence, only heating the assay to a certain constant temperature is essential and this process does not involve any cooling part, unlike the PCR technique. In general, LAMP is executed at a constant temperature of around 60°C to 67°C depending on the assay. Maintaining simultaneously high and constant temperatures at any point-of-care setting is challenging yet achievable. The present work talks about efficient heating strategies that can be implemented in a portable paper-based LAMP device for any POC setting using numerical simulation. The device comprises a 1 mm thick PMMA sheet (6 cm length) at the bottom and top (with sample inlet port), within which a 0.235 mm thick paper membrane (4 cm length) is incorporated for carrying out the LAMP reaction. Isothermal heating is carried out from the bottom of the PMMA sheet. The main aim of this work is to numerically evaluate the effect of the heater length (case 1a - case 1d) and heater position (case 1d' − case 1d^'''') for acquiring the desired LAMP amplification temperature. It was inferred that an effective heater length and position largely influences the energy consumption of the LAMP device. Overall, the numerical simulations were helpful in acquiring the optimal heating strategy.